DOSAGE & ADMINISTRATION:

• Ovarian Cancer: For previously untreated patients with cancer of the ovary:

175 mg/m2 IV over 3 hours followed by cisplatin 75 mg/m2 IV every 3 weeks OR 135 mg/m2 IV over 24 hours followed by cisplatin 75 mg/m2 IV every 3 weeks

For patients previously treated for cancer of the ovary (NOTE: This drug has been used at several doses and schedules; however, the optimal regimen is not yet clear): 135 mg/m2 IV over 3 hours every 3 weeks OR 175 mg/m2 IV over 3 hours every 3 weeks

• Breast Cancer: After failure of initial chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy: 175 mg/m2 IV over 3 hours every 3 weeks
• Breast Cancer – Adjuvant: 175 mg/m2 IV over 3 hours every 3 weeks for 4 courses administered sequentially to doxorubicin-containing chemotherapy
• Non-Small Cell Lung Cancer: 135 mg/m2 IV over 24 hours followed by cisplatin mg/m2 IV every 3 weeks
• Kaposi’s Sarcoma: 135 mg/m2 IV over 3 hours every 3 weeks OR 100 mg/m2 IV over 3 hours every 2 weeks